Topiramate has protective effect on renal injury

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Topiramate has protective effect on renal injury.

BACKGROUND Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. METHODS A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. A...

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ژورنال

عنوان ژورنال: Bratislava Medical Journal

سال: 2015

ISSN: 1336-0345

DOI: 10.4149/bll_2015_050